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Thread: Olanzapine Weight Gain

  1. Default Olanzapine Weight Gain

    Hia,

    I've been taking olanzapine for the past 3 months and even though I've tried to be very careful about what I eat, I've put on half a stone. It's making me very depressed and I've started to make myself sick after meals, though I know this is something I must stop.
    I went to the doctor the other day and she said she was going to switch my tablets as the zyprexa isn't really working for me anyway. My question is this - after I stop taking the olanzapine will it be easy for me to lose the weight I've gained? Baring in mind I exercise every day and don't eat much junk food.

    Thankyou for your help,
    x

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  3. Also, does anyone else here take Olanzapine (or have done in the past) and experienced a lot of weight gain?
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    Personality changes and weight gain are two of the common side effects of olanzapine. Ideally, you should lose the weight you gained with olanzapine after you stop taking it. However, clinical trial shows that there are adverse effects when discontinuing this drug. You should discuss what to expect with your doctor.

  5. most of the drugs in this category will cause weight gain from increased appetite
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  6. Not only will zyprexa cause weight gain, there is a risk of developing diabetes with this drug. I think it should be pulled from the market but shrinks seem to think its the nectar of the gods.
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  7. Ask your doctor to switch you to Geodon (Ziprasidone)...

    Same mechanism as all the other atypical antipsychotics...

    Only one that is NOT associated with weight gain...

    You don't have any heart conditions do you?
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    I've taken about 10Lbs on Seroquel (Quetiapine). But as mentionned earlier in this thread It's stabilized somewhat after stopping the medication. In my opinion it was not worth the weight gain. All it does is make you sleep all the time and slows your brain down.
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  9. #8
    Quote Originally Posted by Non Displaced View Post
    Ask your doctor to switch you to Geodon (Ziprasidone)...

    Same mechanism as all the other atypical antipsychotics...

    Only one that is NOT associated with weight gain...

    You don't have any heart conditions do you?
    That's not true. They are ALL associated with weight gain, although that one happens to be the best of the class for that. The worst are olanzapine and clozapine.
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    Quote Originally Posted by jgrn87 View Post
    That's not true. They are ALL associated with weight gain, although that one happens to be the best of the class for that. The worst are olanzapine and clozapine.

    I would have to respectfully disagree with this. During my appointment a couple of days ago with my psychiatrist I asked why I was losing weight whilst taking Seroquel she said it was probably due to the fact that I also take Topiramate as a migraine prophylactic. This lead to a discussion about a smaller breakdown I'd had a few years ago when I was given Aripiprazole (Abilify). I only took it for a month due to the very dramatic weight loss it caused (I wasn't taking Topiramate at the time). She said it was a general rule of thumb that people taking Abilify either gained no weight or lost a small amount of weight. She said that only very rarely had she seen people gain any weight whilst taking Abilify.

    She also said it was contra-indicated for individuals with comorbid psychosis and eating disorders because of the potential weight loss.

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  11. #10
    @miffytherabbit

    Here are a few abstracts to read, this won't give you access to the full papers however. They are listed from oldest to most recent:
    A comparison of weight change during treat... [J Clin Psychiatry. 2004] - PubMed - NCBI
    A multicenter, randomized, double-blind st... [J Clin Psychiatry. 2008] - PubMed - NCBI
    Changes in weight and other m... [Clin Schizophr Relat Psychoses. 2011] - PubMed - NCBI
    Weight gain and metabolic ri... [J Child Adolesc Psychopharmacol. 2011] - PubMed - NCBI
    Aripiprazole: a review of its use in the managemen... [CNS Drugs. 2012] - PubMed - NCBI

    The first two articles note that weight loss was observed in the aripiprazole groups, in general, although weight gain was still an issue in some patients.

    Here is a quote from one of the more recent articles talking about switching someone on an antipsychotic to aripiprazole: "With respect to weight, our results indicate that there is a high probability that obese or overweight patients taking other antipsychotic medications will lose weight and decrease their waist circumference if switched to aripiprazole."

    I did read a few more articles, and there does not appear to be much consensus on the issue. There is agreement that people lose weight when switching from a different antipsychotic to aripiprazole, although studies where patients are started on an antipsychotic aren't as clear. They generally show that aripiprazole is better than the other antipsychotics in terms of weight gain, although some studies show no increase in weight while others show weight gain (although not as much as with antipsychotics). In those studies, there are also cases of weight loss reported, although you have to wonder whether this was intentional weight loss (through increased exercise and dieting) rather than an adverse effect of the medication.

    So in the end, I guess I can't really give a clear answer, because there isn't really a consensus amongst experts on this issue. It is true that arirpiprazole does not have as much of an issue with weight gain as the other antipsychotics, but it is difficult to say that it causes no weight gain based on the current evidence. Certainly, switching from a different antipsychotic to aripirazole will result in weight loss, and this is well proven, but weight loss in someone starting ariprazole as their first antipsychotic is debatable. There are certainly cases where this occurs, but one has to wonder whether it is the antipsychotic causing this, or simply the fact that it is weight neutral in those people and they know that antipsychotics cause weight gain, so they modify their lifestyle as a result.

    Either way it's an interesting topic, and thanks for bringing it up as I learned some things which I previously didn't know.

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    When I was prescribed olanzapine, I gained nearly 30 pounds in less than six weeks. Had I not discontinued the medication, I also probably would have developed diabetes, as it gave me an insatiable appetite for sugar (I would literally wake up at night to eat cake icing from the jar with a spoon).

    I switched to quetiapine (Seroquel) and, while it does enhance my appetite,it has not caused me to gain any additional weight, and I have lost about 2/3rd's of the weight I gained while on olanzapine.
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    Quote Originally Posted by bradleyolson View Post
    I switched to quetiapine (Seroquel) and, while it does enhance my appetite,it has not caused me to gain any additional weight, and I have lost about 2/3rd's of the weight I gained while on olanzapine.
    It depend on organism. I know persons which inversely seroquel causes weight gain, and zyprexa has not caused them to gain any additional weight.
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    Zyprexa can cause major weight gain, even if your eating habits do not change (which they probably will, because as said it increases your appetite ten fold.)
    What it ALSO does is cause your body to take calories for energy from your fat and protein stores, not carbohydrates, therefore increasing your risk for developing diabetes. Your body gains a build-up of refined sugars, which have a whole host of negative effects on your system, including slowing your metabolism. Oh joy.
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  15. simply said: olanzapine messes with your metabolism and should therefore be taken of the market. but that's just my opinion. there may be others who profit from taking olanzapin and accept the gain of weight.
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  16. #15
    A new (internal medicine - not a shrink) dr prescribed olanzapine for me after talking with me for about 15 minutes when I was very upset from arguing with husband on the way to the drs. (It IS all husbands' fault! You can't live with them and you can't get credit card without them - I know that's not PC & I'm hoping no one writes me back for saying that old joke! And I do have my own credit..
    When I got home and looked it up - oh my god!! Oh sheesh - unbelievable. It messes with 5 different brain things, not just one - you know synapses & all that. People gain 10 lbs a week & feel sedated. I have PTSD pretty bad & the worst of it is intrusive thoughts about things that happened/things I should have stood up for, but didn't - guilt. He said this would stop those thoughts but it sounds like it stops a lot more than just the intrusive thoughts.
    Personally I'm thinking of joining the Mormons! Really. They're happy and lead good lives - I can use the AA mantra "Fake it til you make it" since no, I don't really believe it or any other church but as George Castanza said about the Greek Orthodox - "so what does it matter?" I need to feel forgiven, not sedated.

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    I use stmilants to prevent the insatiable appetite induced by olanzapine,and told my shrink I will keep doing so until she switches to pramipexole, a dopamine agonist designed to replace antipsychotics in the treatment of Biopler. All antipschotics were designed to treat schzophrenia not BP. Interestingly weigh loss is one of pramipexole's side effects. I am growing tired of huge costs in food and new cllothes
    Last edited by Kfer; 11-23-2014 at 11:41 PM.

  18. #17
    Quote Originally Posted by Kfer View Post
    I use stmilants to prevent the insatiable appetite induced by olanzapine,and told my shrink I will keep doing so until she switches to pramipexole, a dopamine agonist designed to replace antipsychotics in the treatment of Biopler. All antipschotics were designed to treat schzophrenia not BP. Interestingly weigh loss is one of pramipexole's side effects. I am growing tired of huge costs in food and new cllothes

    Hi . Have you changed your drug yet. I have been on every single antiphycotic and now just use benzos..about 5 docs say I have bi polar .But it would be Intersting to see if that drug works for you.

    In the UK. Using it for bi polar would be off label. The nhs uses it for Parkinson's disease and restless leg syndrome only.

  19. Hi,

    Zyprexa has been a God Send to me over the last 13 years, I don't know where I would be without it, got me out of some very suicidal feelings whilst trying out different antidepressants.

    I initially took 10mg once a week and I felt hungry all of the time, I would eat anything but I also smoke quite heavily so that kind of stopped me putting on weight. Also, just taking 10mg once a week would mean that the increased hunger would subside.

    I'm not sure how much you were taking but I have taken 2.5mg of Zyprexa on a regular basis and didn't put any weight on but then as I already said I smoke so that probably helped.

    I do know that Zyprexa is renown for making people put on weight and I can understand why.

    Denise

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    Quote Originally Posted by rune View Post
    Hi . Have you changed your drug yet.
    Yes I have and the need for anorectic drugs to control my appetite is all but gone.

    In the UK. Using it for bi polar would be off label. The nhs uses it for Parkinson's disease and restless leg syndrome only.
    It's still an uncommon use for it here but patients losing patience over the obesity-promoting atypical antipsychotics used to treat BPD are creating a growing demand for alternatives, as do psychiatrists having to cope with the unprecedented number of patients who abandon their treatment owing to this side effect which in itself represents such a health hazard, what with diabetes and heart disease implications, that skepticism over their use is growing even among mental health specialists, especially since long-overdue independent studies seem to contradict industry claims regarding their risk/benefit ratio. Not to mention embarrassing lawsuits over the matter.

    Regarding use of pramiprexole for RLS it never ceases to to startle me that drugs known for causing akithesia are promoted for treating what is essentially a localized manifestation of the syndrome. So far the only effective treatment for RLS are benzodiazepines, that's why the worst offender in this regard, Haldol (haloperidol) is now only given alongside with lorazepam.

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    I was prescribed Olanazapine by a shrink, I think because at the time I was having some pretty weird thought patterns centred around disasters and the end of the world (I got over it). All I can say it probably did help with stopping those thoughts but I did gain about 30 pounds in six months, I have the photos to prove it! It just gave me an insatiable appetite which had never been an issue for me, I never used to snack or eat large breakfasts and lunches before I started taking it. I would have probably gained even more weight but I was pretty physically active at that time.

  22. Olanzapine Weight Gain
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