Topamax is often used in conjunction with an antipsychotic. It is known as a somewhat effective mood stabilizer. The benefit of using topamax along with a drug like seroquel or zyprexa is that for many people it causes significant weight loss. There is even a diet pill on the market that combines phentermine with topamax to induce even more weight loss than phentermine alone. Every Dr. that I have seen has prescribed this along with my regimen. Topamax does not work for me in terms of weight loss but for many, many people it does.