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Thread: The longer the depression, the less likely ADs are to work?

  1. #1
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    Default The longer the depression, the less likely ADs are to work?

    I just read a study that compared Sertraline (Zoloft) to Venlafexine (Effexor) and among other things, it mentioned the patients who had "episodes" of depression that lasted longer than 6 months, had worse outcomes from usage of either of those medications, and actually felt worse at the 8 week mark. Those with shorter episodes of depression of less than 6 months showed a marked improvement at the 6 and 8 week mark.

    I find this finding rather bleak, as my own depression doesn't manifest as "episodes". 6 months only?? That to me would suggest an external cause or temporary problem, or some kind of cyclic mood issue.

    I have felt the same for about the last 5 years and to a lesser extent, 10-20 years. Depression for me is my baseline, not an "episode".

    Is depression SUPPOSED to be episodic?? Does everyone with constant long term depression not respond to AD meds?
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    I don’t know if it’s “supposed” to be episodic, but it is for a lot of people. I’m diagnosed as bipolar, so obviously it is very episodic for me. My manic phases last for a few days but the depression usually goes on for 6-9 months. Antidepressants have never worked for me. I think I read somewhere that 20% of folks diagnosed with depression don’t respond to antidepressants (but don’t quote me on that).
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    Quote Originally Posted by dearie23 View Post
    I just read a study that compared Sertraline (Zoloft) to Venlafexine (Effexor) and among other things, it mentioned the patients who had "episodes" of depression that lasted longer than 6 months, had worse outcomes from usage of either of those medications, and actually felt worse at the 8 week mark. Those with shorter episodes of depression of less than 6 months showed a marked improvement at the 6 and 8 week mark.

    I find this finding rather bleak, as my own depression doesn't manifest as "episodes". 6 months only?? That to me would suggest an external cause or temporary problem, or some kind of cyclic mood issue.

    I have felt the same for about the last 5 years and to a lesser extent, 10-20 years. Depression for me is my baseline, not an "episode".

    Is depression SUPPOSED to be episodic?? Does everyone with constant long term depression not respond to AD meds?
    I think you are spot on here. I know a tad based on a friends experience. I also did some research into it and kept coming across medical articles mentioning the fact they lose their usefulness.
    Are you able to change between AD's by chance? I know that is a horror. Still- if you are stuck in the deep reaches of depression you have to do something right?

    Do you have an option to try Ketamine IV? I know it is not a success for all but I do know those that have had luck with it. The darn ketamine clinics are popping up all over the place at least in these parts.

    I don't think it is a permanent help but perhaps get you over a bump.

    Also, eskatamine should be around soon. A nasal spray for it.

    All I can say is as a pain patient in a hell of a bind- ketamine was useful the few times I could get it (well not from my doc sadly).

    I don't want to pony up the $ for IV that won't last long enough for me but I will say the little I had to get through a holiday was amazingly helpful without any drop out if you follow me.

    I am so sorry you are going through what you are. I do know what it feels like and I deal with it at times. Episodic I guess but a bit of permanence also.
    I cannot do AD's myself. Just don't get along.

    I was surprised the first time I heard about AD's "wearing off" and losing efficacy.
    Good luck to you.
    Call on God, but row away from the rocks

  5. The longer the depression, the less likely ADs are to work?

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