Zoral (Aciclovir)

 
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Zoral is one brand name of the medicine also known by its generic name Aciclovir. This page displays only reviews left by users of Zoral. Click here to see all reviews left for all forms of Aciclovir. You can also choose other review combinations.

More about Aciclovir

What is/are Aciclovir?

Aciclovir (INN) /eɪˈsaɪklɵvɪər/ or acyclovir (USAN, former BAN), chemical name acycloguanosine, abbreviated as ACV, is a guanosine analogue antiviral drug, marketed under trade names such as Cyclovir, Herpex, Acivir, Acivirax, Zovirax, Zoral, and Xovir. One of the most commonly used antiviral drugs, it is primarily used for the treatment of herpes simplex virus infections, as well as in the treatment of varicella zoster (chickenpox) and herpes zoster (shingles).

Medical uses

Aciclovir is indicated for the treatment of HSV and VZV infections, including:

  • Genital herpes simplex (treatment and prophylaxis)
  • Herpes simplex labialis (cold sores)
  • Herpes zoster (shingles)
  • Acute chickenpox in immunocompromised patients
  • Herpes simplex encephalitis
  • Acute mucocutaneous HSV infections in immunocompromised patients
  • Herpes simplex keratitis (ocular herpes)
  • Herpes simplex blepharitis (not to be mistaken with ocular herpes)
  • Prophylaxis against herpesviruses in immunocompromised patients (such as patients undergoing cancer chemotherapy)

It has been claimed that the evidence for the effectiveness of topically applied cream for recurrent labial outbreaks is weak. An earlier review of scientific literature showed there is some effect in reducing the number and duration of lesions if aciclovir is applied at an early stage of an outbreak. However, oral therapy for episodes was found to be inappropriate for most nonimmunocompromised patients based on costs and benefits, presumably in countries where aciclovir is only available on prescription. There is evidence for an oral prophylactic role in preventing recurrences.

Aciclovir trials show that this agent has no role in preventing HIV transmission, but it can help slow HIV disease progression in people not taking anti-retroviral therapy (ART). This finding emphasizes the importance of testing simple, inexpensive non-ART strategies, such as aciclovir and cotrimoxazole, in people with HIV.

Dosage and route

Aciclovir is commonly marketed as tablets (200 mg, 400 mg, 800 mg and 1 gram), topical cream (5%), intravenous injection (25 mg/mL) and ophthalmic ointment (3%).

  • Cream preparations are used primarily for labial herpes simplex.
  • The ophthalmic ointment preparation is only used for herpes simplex keratitis.
  • The intravenous injection is used when high concentrations of aciclovir are required such as in in HSV encephalitis, Acute retinal necrosis, and disseminated zoster disease

Adverse effects

Systemic therapy

Common adverse drug reactions (≥1% of patients) associated with systemic aciclovir therapy (oral or IV) include: nausea, vomiting, diarrhea and/or headache. In high doses, hallucinations have been reported. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, oedema, arthralgia, sore throat, constipation, abdominal pain, hair loss, rash and/or weakness. Rare adverse effects (<0.1% of patients) include: coma, seizures, neutropenia, leukopenia, crystalluria, anorexia, fatigue, hepatitis, Stevens–Johnson syndrome, toxic epidermal necrolysis and/or anaphylaxis.

Additional common adverse effects, when aciclovir is administered IV, include encephalopathy (1% of patients) and injection site reactions. The injection formulation is alkaline (pH 11), and extravasation may cause local tissue pain and irritation.

Intravenous acyclovir may cause reversible nephrotoxicity in 5% to 10% of patients because of precipitation of acyclovir crystals in kidney. Acyclovir crystalline nephropathy is more common when acyclovir is given as a rapid infusion and in patients with dehydration and preexisting renal impairment. Adequate hydration, a slower rate of infusion, and dosing based on renal function may reduce this risk.

Topical therapy

Aciclovir topical cream is commonly associated (≥1% of patients) with: dry or flaking skin or transient stinging/burning sensations. Infrequent adverse effects include erythema or itch. When applied to the eye, aciclovir is commonly associated (≥1% of patients) with transient mild stinging. Infrequently (0.1–1% of patients), ophthalmic aciclovir is associated with superficial punctate keratitis or allergic reactions.

Toxicity

Since cellular DNA can incorporate aciclovir into itself, the drug acts as a chromosome mutagen; therefore it "...should not be used during pregnancy unless the potential benefit justifies the potential risk to the foetus..." However, it has not been shown to have any teratogenic or carcinogenic effects and is frequently prescribed for pregnant women, to prevent transmission of HSV to the neonate. The acute toxicity (LD50) of aciclovir when given orally is greater than 1 g/kg, due to its low oral bioavailability.[citation needed] Patients with renal impairment often exhibit elimination half-lives for the drug that are five to six times longer than in those with normal renal function, leading to accumulation of aciclovir in the plasma and the likelihood of development of toxic reactions, such as lethargy, confusion and myoclonus.

Cotard delusion has also been the result of adverse drug reactions to aciclovir. The symptoms were associated with high serum concentrations of 9-carboxymethoxymethylguanine (CMMG), the principal metabolite of aciclovir.

Detection in biological fluids

Aciclovir may be quantitated in plasma or serum to monitor for drug accumulation in patients with renal dysfunction or to confirm a diagnosis of poisoning in acute overdose victims.

This article uses material from the Wikipedia article Aciclovir , which is released under the Creative Commons Attribution-Share-Alike License 3.0.

 

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