Albuterol inhalation

 
4.7 (1)
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More about Albuterol inhalation

What is/are Albuterol inhalation?

Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease. It is marketed as Ventolin among other brand names.

Salbutamol was the first selective β2-receptor agonist to be marketed – in 1968. It was first sold by Allen & Hanburys under the brand name Ventolin. The drug was an instant success, and has been used for the treatment of asthma ever since.

Salbutamol sulfate is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.

Medical uses

Salbutamol is typically used to treat bronchospasm (due to either allergen asthma or exercise-induced), as well as chronic obstructive pulmonary disease.

Other uses include in cystic fibrosis, along with ipratropium bromide, acetylcysteine, and pulmozyme and subtypes of congenital myasthenic syndromes associated to mutations in Dok-7.

As a β2-agonist, salbutamol also finds use in obstetrics. Intravenous salbutamol can be used as a tocolytic to relax the uterine smooth muscle to delay premature labor. While preferred over agents such as atosiban and ritodrine, its role has largely been replaced by the calcium-channel blocker nifedipine, which is more effective, better tolerated and orally administered.

Salbutamol has been used in treating acute hyperkalemia on account of its potassium-depleting properties by stimulating potassium inflow in cells.

Salbutamol has also been trialled in spinal muscular atrophy where it appears to show modest benefits. The drug is speculated to modulate the alternative splicing of the SMN2 gene, increasing the amount of the SMN protein whose deficiency is regarded as the root cause of the disease.

Adverse effects

The most common side effects are fine tremor, anxiety, headache, muscle cramps, dry mouth, and palpitation. Other symptoms may include tachycardia, arrhythmia, flushing, myocardial ischemia (rare), and disturbances of sleep and behaviour. Rarely occurring, but of importance, are allergic reactions of paradoxical bronchospasm, urticaria, angioedema, hypotension, and collapse. High doses may cause hypokalaemia, which is of concern in patients with renal failure and those on certain diuretics and xanthine derivatives.

This article uses material from the Wikipedia article Albuterol inhalation, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

Reviews for Albuterol inhalation

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1 reviews

Overall rating 
 
4.7
Overall satisfaction 
 
5.0  (1)
Efficacy  
 
5.0  (1)
Lack of side effects 
 
4.0  (1)
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Overall rating 
 
4.7
Overall satisfaction 
 
5.0
Efficacy  
 
5.0
Lack of side effects 
 
4.0
Rescue inhaler

My asthma has been in very good control for years.
Still, I keep an albuterol inhaler with me at all times.
If I am ever exposed to known allergans (like cat dander, tree pollen, dust mite #3) I can rapidly need a rescue inhaler.
Also if I have a garden variety cold, I may use it every 6-8 hours or so, prophylactically.

In a few instances, my asthma was not well controlled with this medication. A sign of this is needing to use it more often than every 4 hours (which is considered unsafe). At those times, I usually need a short burst of oral Prednisone (4 days) or so.
Sometimes the addition of a steroid inhaler works instead of the oral Prednisone (if I haven't waited too long to start this)

It can be hard to get the first puff in if one is struggling to breathe, so an inspirease bag is useful.
I usually wait a few minutes between puffs to let the first puff absorb, making it more likely the lungs will expand to better "take in" the second puff.
The times I have needed to take this medication every 4 hours, I can say that the only side effect I noticed was some brief tachycardia.
Nothing severe though.



Relevant Brand Name and Medical Condition

Brand Name
Ventolin HFA
Medical Condition
Asthma

Additional Information

How long have you taken this medicine for?
More than 2 years
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