Drug Name: XANAX
COMMON XANAX BRAND NAME(S):
XANAX SIDE EFFECTS:
Drowsiness, incoordination, headache, fatigue, change in sex drive, change in appetite, change in weight, difficulty urinating or stomach upset may occur the first few days as your body adjusts to the medication. If any of these effects continue or become bothersome, inform your doctor. To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use saliva substitute. Notify your doctor if you develop: rapid/pounding/irregular heartbeat, skin rash, changes in vision, slurred speech, confusion, depression, behavioral changes. If you notice other effects not listed above, contact your doctor or pharmacist.
HOW TO USE XANAX:
XANAX: Take XANAX by mouth exactly as prescribed. Do not take this more often, increase your dose or take this longer than directed without consulting your doctor. Do not suddenly stop taking XANAX if you have been taking this regularly for several weeks. Your dose will need to be gradually decreased to prevent side effects.
XANAX has a calming effect. It is used to relieve anxiety, nervousness and tension in the treatment of anxiety disorders and panic disorders.
Tell your doctor if you have: kidney problems, liver disease, glaucoma, muscle weakness, history of drug dependence, any allergies. XANAX may cause drowsiness or dizziness. Use caution operating machinery or engaging in activities requiring alertness. Limit intake of alcohol while taking XANAX since it may aggravate drowsiness and dizziness. Alprazolam is is not recommended for use during pregnancy. Consult your doctor before using XANAX. XANAX passes into breast milk and may harm a nursing infant. Nursing while using alprazolam is not recommended. Consult your doctor before breast-feeding. The elderly may be more sensitive to the effects of this medication and should use XANAX carefully.
XANAX DRUG INTERACTIONS:
Tell your doctor of any over-the-counter or prescription medication you take, including: anti-seizure drugs, antidepressants, narcotic pain relievers, erythromycin-like antibiotics, cimetidine, sleeping pills, tranquilizers, azole antifungals. Do not start or stop any medicine without doctor or pharmacist approval.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include confusion, slow reflexes, clumsiness, deep sleep, and loss of consciousness.
XANAX when used in high doses or for prolonged periods of time can lead to dependence. Therefore, it is important to follow your dosing instructions closely.
MISSED XANAX DOSE:
If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Store XANAX at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat, light and moisture. Do not store in the bathroom. Keep this and all medications out of the reach of children.
Detection in body fluids
Alprazolam may be quantitated in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest or to assist in a medicolegal death investigation. Blood or plasma alprazolam concentrations are usually in a range of 10–100 μg/L in persons receiving the drug therapeutically, 100–300 μg/L in those arrested for impaired driving and 300–2000 μg/L in victims of acute overdosage. Most commercial immunoassays for the benzodiazepine class of drugs will cross-react with alprazolam, but confirmation and quantitation is usually performed using chromatographic techniques.
Alprazolam is classed as a high-potency benzodiazepine and is a triazolobenzodiazepine, namely a benzodiazepine with a triazole ring attached to its structure. Benzodiazepines produce a variety of therapeutic and adverse effects by binding to the benzodiazepine receptor site on the GABAA receptor and modulating the function of the GABA receptor, the most prolific inhibitory receptor within the brain. The GABA chemical and receptor system mediates inhibitory or calming effects of alprazolam on the nervous system. The GABAA receptor is made up of 5 subunits out of a possible 19, and GABAA receptors made up of different combinations of subunits have different properties, different locations within the brain, and, importantly, different activities with regard to benzodiazepines. Benzodiazepines and in particular alprazolam causes a marked suppression of the hypothalamicpituitary-adrenal axis. The therapeutic properties of alprazolam are similar to other benzodiazepines and include anxiolytic, anticonvulsant, muscle relaxant, hypnotic and amnesic.
Administration of alprazolam has been demonstrated to elicit an increase in striatal dopamine concentrations.
Alprazolam was first released by Upjohn (now a part of Pfizer). It is covered under U.S. Patent 3,987,052, which was filed on 29 October 1969, granted on 19 October 1976, and expired in September 1993. Alprazolam was released in 1981. The first approved indication was panic disorder. Alprazolam was originally perceived to have been a poor investment, as Upjohn management did not believe there to be a market for panic disorder-oriented anxiolytics. However, alprazolam soon proved itself in clinical phase, FDA-mandated trials. It become a blockbuster drug with two years of its original marketing in the US market. Today, it is clinically known for not only anxiolytic properties, but also a forgiving and statistically significant anti-depressant profile, given its triazolebenzodiazepine skeletal structure, it does maintain some affinity for serotonergic receptors. Today it is the most commonly prescribed benzodiazepine in the United States, and has been available as generic instant-release and extended-release tablets for years.
Alprazolam may be also be indicated for the treatment of Generalized Anxiety Disorder, as well as for the treatment of anxiety conditions with co-morbid depression. Alprazolam is also often prescribed with instances of hypersomnia and co-morbid sleep deficits.
This article uses material from the Wikipedia article Alprazolam , which is released under the Creative Commons Attribution-Share-Alike License 3.0.