Benzydamine

 
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More about Benzydamine

What is/are Benzydamine?

Benzydamine (also known as Tantum Verde and branded in some countries as Difflam), available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.

Medical uses

Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy.

Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis.

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.

In some markets, the drug is supplied as an over-the-counter cream (Lonol in Mexico from Boehringer Ingelheim) used for topical treatment of musculoskeletal system disorders: sprains, strains, bursitis, tendinitis, synovitis, myalgia, periarthritis.

Contraindications

There are no contraindications to the use of benzydamine except for known hypersensitivity.

Side effects

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur.

Pharmacology

It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) and is normally free of adverse systemic effects. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.

Recreational use

Benzydamine has been misused recreationally. In overdosages it acts a deliriant and CNS stimulant. Such misuse, particularly among teenagers, has been reported in Poland, Brazil and Romania.

In Brazil, the substance is sold by the name Benflogin and it is very effective for treating a sore throat. It is very strong at 50mg each pill, so even 2-5 pills can and will trigger the delirant and stimulant effects in some people.

This article uses material from the Wikipedia article Benzydamine , which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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