Captopril

 
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More about Captopril

What are captopril tablets?

CAPTOPRIL (Capoten®) is an antihypertensive (blood pressure lowering agent) known as an ACE inhibitor. Captopril controls high blood pressure (hypertension) by relaxing blood vessels; it is not a cure. High blood pressure levels can damage your kidneys, and may lead to a stroke or heart failure. Captopril also can help to treat heart failure (heart does not pump strongly enough) and certain kidney disorders. Generic captopril tablets are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• autoimmune disease or collagen-vascular disease (such as lupus)
• suppressed immune function
• previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat (angioedema)
• bone marrow disease
• heart or blood vessel disease
• liver disease
• low blood pressure
• kidney disease
• if you are on a special diet, such as a low-salt diet
• an unusual or allergic reaction to captopril, other ACE inhibitors, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on your prescription label. Take this medicine on an empty stomach, 1 hour before meals. Take your doses at regular intervals. Do not take more medicine than directed. Do not stop taking this medicine except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with captopril?

• antacids
• antiinflammatory drugs (NSAIDs, such as ibuprofen)
• aspirin and aspirin-like medicines
• digoxin
• gold compounds, often used for arthritis
• heparin
• lithium
• medicines for diabetes
• medicines for high blood pressure
• monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar™)
• potassium salts
• probenecid
• water pills

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking captopril?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• chest pain, uneven or fast heart beat, palpitations
• decreased or increased amount of urine passed
• difficulty breathing, or difficulty swallowing
• dizziness, lightheadedness or fainting spells
• fever or chills
• numbness or tingling in your fingers or toes
• skin rash, itching
• swelling of your face, lips, or tongue
• swelling of your legs or ankles

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• cough
• loss of taste
• fatigue or tiredness
• increased sensitivity to the sun

What should I watch for while taking captopril?

Visit your prescriber or health care professional for regular checks on your progress. Check your blood pressure regularly while you are taking captopril. Ask your prescriber or health care professional what your blood pressure should be and when you should contact him or her. Call your prescriber or health care professional if you notice an uneven or fast heart beat. Do not treat yourself for a fever or sore throat; check with your prescriber or health care professional as these may be the result of a captopril side effect.

Check with your prescriber or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of body fluid can make it dangerous to take captopril.

You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how captopril affects you. To avoid dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older person. Alcohol can make you more dizzy. Avoid alcoholic drinks.

If you are going to have surgery, tell your prescriber or health care professional that you are taking captopril.

Avoid salt substitutes or other foods or substances high in potassium salts.

Do not treat yourself for coughs, colds, or pain while you are taking captopril without asking your prescriber or health care professional for advice.

Antacid can stop captopril working. If you want to take antacid for an upset stomach, make sure there is an interval of at least 2 hours since you last took captopril, or 4 hours before your next dose.

Captopril can alter certain lab test results, giving a false-positive for urine ketone tests.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature below 30 degrees C (86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.

What is/are Capoten?

CAPTOPRIL is an ACE inhibitor. This medicine is used to treat high blood pressure and heart failure. It is used to treat heart damage after a heart attack. It can also slow the progression of kidney disease in diabetic patients. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of these conditions:

  • bone marrow disease
  • heart or blood vessel disease
  • if you are on a special diet, such as a low salt diet
  • immune system disease like lupus or scleroderma
  • kidney disease
  • low blood pressure
  • previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
  • an unusual or allergic reaction to captopril, other ACE inhibitors, insect venom, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on your prescription label. Take this medicine on an empty stomach, at least 1 hour before meals. Take your doses at regular intervals. Do not take more medicine than directed. Do not stop taking this medicine except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • antacids
  • diuretics
  • lithium
  • medicines for chest pain like nitroglycerin
  • medicines for high blood pressure
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • over-the-counter herbal supplements like hawthorn
  • potassium salts or potassium supplements

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • chest pain
  • dark urine
  • feeling faint or lightheaded, falls
  • fever or sore throat
  • irregular heart beat
  • pain or difficulty passing urine
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • stomach pain with or without nausea or vomiting
  • unusually weak
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance
  • cough
  • loss of taste
  • sun sensitivity
  • tiredness

This list may not describe all possible side effects.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her. Call your doctor or health care professional if you notice an irregular or fast heart beat.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Avoid salt substitutes unless you are told otherwise by your doctor or health care professional.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

Where should I keep this medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.

Medical uses

Captopril's main uses are based on its vasodilation and inhibition of some renal function activities. These benefits are most clearly seen in the following conditions:

1) Hypertension

2) Cardiac conditions such as congestive heart failure and after myocardial infarction

3) Preservation of kidney function in diabetic nephropathy

Additionally, it has shown mood-elevating properties in some patients. This is consistent with the observation that animal screening models indicate putative antidepressant activity for this compound, although there has been one negative study. Formal clinical trials in depressed patients have not been reported.

It has also been investigated for use in the treatment of cancer.

Adverse effects

Adverse effects of captopril include cough due to increase in the plasma levels of bradykinin, angioedema, agranulocytosis, proteinuria, hyperkalemia, taste alteration, teratogenicity, postural hypotension, acute renal failure and leukopenia. Except for postural hypotension, which occurs due to short and fast mode of action of captopril, most of the side effects mentioned are common for all ACE inhibitors. Among these, cough is the most common adverse effect. Hyperkalemia can occur, especially if used with other drugs which elevate potassium level in blood, such as potassium-sparing diuretics. Other side effects are:

  • Itching
  • Headache
  • Tachycardia
  • Chest pain
  • Palpitations
  • Weakness

Mnemonic for CAPTOPRIL side effects: Cough, Angioedema, Proteinuria, Taste change, hypOtension, Pregnancy problems, Rash, Increased renin, Lower pressure (lack of vasoconstriction)

Overdose

Captopril (as other ACE inhibitors) overdose can be antagonized with naloxone.

This article uses material from the Wikipedia article Captopril, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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