0.0 (0)
This page displays reviews written by users of all forms of Ceftriaxone. You can also choose to see reviews only for a specific medical condition or brand name.

More about Ceftriaxone

What is/are Ceftriaxone?

Ceftriaxone (INN) /ˌsɛftraɪˈæksoʊn/ is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy. Ceftriaxone sodium is marketed by Hoffmann-La Roche under the trade name Rocephin.

Medical uses

Ceftriaxone is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is commonly used in febrile infants between 4 and 8 weeks of age who are admitted to the hospital to exclude sepsis. The dosage for acute ear infection in the very young is 50 mg/kg IM, one dose daily up to three days. It has also been used in the treatment of Lyme disease, typhoid fever, and gonorrhea.

Intravenous dosages may be adjusted for body mass in younger patients and is administered every 12–24 hours, at a dose that depends on the type and severity of the infection.

For the treatment of gonorrhea, a single intramuscular injection is usually given. According to the Journal of Family Practice, Volume 60, NO 12, December 2011; the intramuscular dose of ceftriaxone (Rocephin) has been increased from 125 mg IM to 250 mg IM due to increasing resistance of the gonococcal bacteria. It is also recommended that 1000 mg of azithromycin be given orally at the same time for dual treatment. This also takes care of treatment of underlying chlamydia since treatment for chlamydia infection is also recommended. It must not be mixed or administered simultaneously (within 48 hours) with calcium-containing solutions or products for patients younger than 28 days old, even via different infusion lines (rare fatal cases of calcium-ceftriaxone precipitates in lung and kidneys in neonates have been described).

To reduce the pain of intramuscular injection, ceftriaxone may be reconstituted with 1% lidocaine.

Ceftriaxone has also been investigated for efficacy in preventing relapse to cocaine addiction.

Ceftriaxone seems to increase EAAT2 pump expression and activity in the central nervous system and has therefore a potential to reduce glutamatergic toxicity.

Ceftriaxone has been shown to have neuroprotective properties in a number of neurological disorders, including spinal muscular atrophy and amyotrophic lateral sclerosis. Despite earlier negative results in the 1990s, a large clinical trial was undertaken in 2006 to test ceftriaxone in ALS patients but was stopped early after it became clear that the results wouldn't meet the pre-determined criteria for efficacy. 

Adverse effects

Hypoprothrombinaemia and bleeding are specific side effects. Haemolysis is reported. Biliary sludging is another known though rare adverse effect which occurs primarily in neonates.

This article uses material from the Wikipedia article Ceftriaxone, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

Reviews for Ceftriaxone

See reviews for a different combination of brand names and medical conditions:
There are no user reviews for this listing.
Already have an account?
Overall satisfaction
Lack of side effects
Relevant Brand Name and Medical Condition
Additional Information
Please tell us about your experience with this medicine