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More about Diltiazem

What is/are Tiazac Extended-Release Capsules?

DILTIAZEM is a calcium-channel blocker. It affects the amount of calcium found in your heart and muscle cells. This relaxes your blood vessels, which can reduce the amount of work the heart has to do. This medicine is used to treat high blood pressure and chest pain caused by angina. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of these conditions:

heart problems, low blood pressure, irregular heartbeat liver disease previous heart attack an unusual or allergic reaction to diltiazem, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Swallow whole, do not crush or chew. Ask your doctor or pharmacist if your should take this medicine with food. Take your doses at regular intervals. Do not take your medicine more often then directed. Do not stop taking except on the advice of your doctor or health care professional. Ask your doctor or health care professional how to gradually reduce the dose.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following:

cisapride hawthorn pimozide ranolazine red yeast rice

This medicine may also interact with the following:

buspirone carbamazepine cimetidine cyclosporine digoxin local anesthetics or general anesthetics lovastatin medicines for anxiety or difficulty sleeping like midazolam and triazolam medicines for high blood pressure or heart problems quinidine rifampin, rifabutin, or rifapentine

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue confusion, mental depression feeling faint or lightheaded, falls irregular heartbeat redness, blistering, peeling or loosening of the skin, including inside the mouth swelling of the feet and ankles unusual bleeding or bruising, pinpoint red spots on the skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

constipation or diarrhea difficulty sleeping facial flushing headache nausea, vomiting sexual dysfunction weak or tired

This list may not describe all possible side effects.

What should I watch for while using this medicine?

Check your blood pressure and pulse rate regularly. Ask your doctor or health care professional what your blood pressure and pulse rate should be and when you should contact him or her.

You may feel dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more dizzy or increase flushing and rapid heartbeats. Avoid alcoholic drinks.

Where should I keep this medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from humidity. Throw away any unused medicine after the expiration date.


Diltiazem is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. Its pharmacological activity is somewhat similar to verapamil.

It is a potent vasodilator of coronary and peripheral vessels, which reduces peripheral resistance and afterload.

Because of its negative inotropic effect, diltiazem causes a modest decrease in heart muscle contractility and reduces myocardium oxygen consumption. Its negative chronotropic effect results in a modest lowering of heart rate, due to slowing of the sinoatrial node. It results in reduced myocardium oxygen consumption.

Because of its negative dromotropic effect, conduction through the AV (atrioventricular) node is slowed, which increases the time needed for each beat. This results in reduced myocardium oxygen consumption.

Nontherapeutic effects and toxicities

A reflex sympathetic response, caused by the peripheral dilation of vessels and the resulting drop in blood pressure, works to counteract the negative inotropic, chronotropic and dromotropic effects of diltiazem. Undesirable effects include hypotension, bradycardia, dizziness, and flushing.


The drug is indicated for angina:

    Stable angina (exercise-induced) – diltiazem increases coronary blood flow and decreases myocardial oxygen consumption, secondary to decreased peripheral resistance, heart rate, and contractility.

    Variant angina – it is effective owing to its direct effects on coronary dilation.

    Unstable angina (preinfarction, crescendo) – diltiazem may be particularly effective if the underlying mechanism is vasospasm.

For supraventricular tachycardias, diltiazem appears to be as effective as verapamil in treating re-entrant supraventricular tachycardia.

Atrial fibrillation or atrial flutter (PSVT) is another indication. The initial bolus should be 0.25 mg/kg, intravenous (IV).

Because of its vasodilatory effects, diltiazem is useful for treating hypertension. Calcium channel blockers are well tolerated, and especially effective in treating low-renin hypertension.


  • The dose of diltiazem in supraventricular tachycardias is 0.25 mg/kg, slow IV push. Most commonly, a 20 mg IV dose is given to the average-sized patient.

This article uses material from the Wikipedia article Diltiazem, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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