What is/are Persantine Tablets?
DIPYRIDAMOLE is used in patients who have had heart valve replacements. It prevents blood clots and reduces the risk of complications. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care providers before I take this medicine?
They need to know if you have any of the following conditions:
- an unusual or allergic reaction to dipyridamole, tartrazine dye, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
How should I use this medicine?
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
Note: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?
- medicines for myasthenia gravis like neostigmine and pyridostigmine
This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What side effects may I notice from this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- chest pain, tightness
- fast, slow, or irregular heartbeat
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- skin rash
- stomach ache or cramps
This list may not describe all possible side effects.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be, and when you should contact him or her.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Ask your doctor or health care professional before you take non-prescription pain relievers. Avoid aspirin and aspirin-containing products.
If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.
Where should I keep this medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
Mechanism and effects
Dipyridamole inhibits the phosphodiesterase enzymes that normally break down cAMP (increasing cellular cAMP levels and blocking the platelet response to ADP) and/or cGMP (resulting in added benefit when given together with nitric oxide [NO] or statins).
Dipyridamole blocks the thromboxane synthase as well as the thromboxane receptor.
It inhibits the cellular reuptake of adenosine into platelets, red blood cells and endothelial cells leading to increased extracellular concentrations of adenosine.
It also inhibits the enzyme adenosine deaminase, which normally breaks down adenosine into inosine. This inhibition leads to further increased levels of extracellular adenosine.
- Dipyridamole has been shown to lower pulmonary hypertension without significant drop of systemic blood pressure
- It inhibits formation of pro-inflammatory cytokines (MCP-1, MMP-9) in vitro and results in reduction of hsCRP in patients.
- It inhibits proliferation of smooth muscle cells in vivo and has shown to prevent AV-shunt failure in dialysis patients.
- It increases the release of t-PA from brain microvascular endothelial cells
- It results in an increase of 13 - HODE and decrease of 12-HETE in the subendothelial matrix (SEM) and reduced thrombogenicity of the SEM.
- Pretreatment it reduced reperfusion injury in volunteers.
- It has been shown to increase myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy.
- It results in a reduction of the number of thrombin and PECAM-1 receptors on platelets in stroke patients.
- cAMP impairs platelet aggregation and also causes arteriolar smooth muscle relaxation. Chronic therapy did not show significant drop of systemic blood pressure.
- It inhibits the replication of mengovirus RNA.
- It can be used for myocardial stress testing as an alternative to exercise-induced stress methods such as treadmills.
Dipyridamole overdose can be treated with aminophylline which reverses its hemodynamic effects (vasodilation). Symptomatic treatment is recommended, possibly including a vasopressor drug. Gastric lavage should be considered. Administration of xanthine derivatives (e.g., aminophylline) may reverse the hemodynamic effects of dipyridamole overdose. Since dipyridamole is highly protein bound, dialysis is not likely to be of benefit.
This article uses material from the Wikipedia article Dipyridamole, which is released under the Creative Commons Attribution-Share-Alike License 3.0.