4.8 (1)
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More about Entacapone

What is/are Entacapone?

Entacapone (INN) (/ˌɛntəkəˈpoʊn/ or /ɛnˈtækəpoʊn/) is a drug that functions as a catechol-O-methyl transferase (COMT) inhibitor. It is used in the treatment of Parkinson's disease.

When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents COMT from metabolizing L-DOPA into 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD) in the periphery, which does not easily cross the blood brain barrier (BBB). Pharmacologically, entacapone is somewhat similar to carbidopa or benserazide, in that it is an inhibitor of an enzyme that converts L-DOPA into a compound that cannot cross the blood brain barrier. Carbidopa and benserazide inhibit aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine, which cannot cross the blood brain barrier.

Entacapone is a member of the class of drugs known as nitrocatechols.

Side effects

The most frequent undesirable effects caused by entacapone relate to the increased effects of L-DOPA, such as involuntary movements (dyskinesias). These occur most frequently at the beginning of entacapone treatment. Others common side effects are gastrointestinal problems, including nausea and abdominal pains. Diarrhea is a frequently reported and troublesome side effect that can result in unnecessary investigation, but resolves quickly on withdrawal of the drug. Entacapone may cause urine to turn reddish-brown. This is a harmless side effect and is not a cause for concern. In studies with entacapone, some people have reported experiencing a dry mouth.


Entacapone is developed by Orion Pharma and marketed by Novartis under the trade name COMTan in the United States.

Stalevo is another medication developed by Orion Pharma and marketed by Novartis that contains entacapone in combination with carbidopa and levodopa (active ingredients in Sinemet).

This article uses material from the Wikipedia article Entacapone, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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Medicine containing Comtan

Medicine containing Entacapone

This page uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the page and product and does not endorse or recommend this or any other product.

Reviews for Entacapone

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1 reviews

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5.0  (1)
5.0  (1)
Lack of side effects 
4.5  (1)
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pennyc is a member of the Pharmacy Reviewer forum
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Comtan for Parkinsons Disease

NOTE: This review is for using Comtan (entacapone) for the treatment of Parkinsons Disease

I've used Comtan for 15 years in combination with Sinemet. Comtan is used with Sinemet to lessen the "end of dose" effect, where the Sinemet seems to wear off before it's time for the next dose. Comtan extends the dose time of Sinemet so that I don't have to decrease the time between Sinemet doses.

I've noticed no side effects of Comtan specifically. My side effects are attributed to Sinemet, which is why I want to keep my dosing as far apart as possible.

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How long have you taken this medicine for?
More than 2 years
(Updated: July 15, 2014)
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