4.0 (1)
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More about Hyoscyamine

What is/are Hyoscyamine?

Hyoscyamine (also known as daturine) is a tropane alkaloid. It is a secondary metabolite found in certain plants of the Solanaceae family, including henbane (Hyoscyamus niger), mandrake (Mandragora officinarum), jimsonweed (Datura stramonium), tomato (Solanum lycopersicum) and deadly nightshade (Atropa belladonna). It is the levorotary isomer of atropine (third of the three major nightshade alkaloids) and thus sometimes known as levo-atropine. Hyoscyamine should not be confused with hyoscine, an older alternate name for the related nightshade-derived anticholinergic scopolamine for which it is the precursor. Brand names for hyoscyamine include Symax, HyoMax, Anaspaz, Egazil, Buwecon, Cystospaz, Levsin, Levbid, Levsinex, Donnamar, NuLev, Spacol T/S and Neoquess.

Medical uses

Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, diverticulitis, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in palliative care.[5] It may be useful in pain control for neuropathic pain treated with opioids as it increases the level of analgesia obtained. Several mechanisms are thought to contribute to this effect. The closely related drugs atropine and scopolamine and other members of the anticholinergic drug group like cyclobenzaprine, trihexyphenidyl, and orphenadrine are also used for this purpose. When hyoscyamine is used along with opioids or other anti-peristaltic agents, measures to prevent constipation are especially important given the risk of paralytic ileus.

Adverse effects

Side effects include dry mouth and throat, eye pain, blurred vision, restlessness, dizziness, arrhythmia, flushing, and faintness. An overdose will cause headache, nausea, vomiting, and central nervous system symptoms including disorientation, hallucinations, euphoria, sexual arousal, short-term memory loss, and possible coma in extreme cases. The euphoric and sexual effects are stronger than those of atropine but weaker than those of scopolamine, as well as dicycloverine, orphenadrine, cyclobenzaprine, trihexyphenidyl, and ethanolamine antihistamines like phenyltoloxamine.

This article uses material from the Wikipedia article Hyoscyamine, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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Reviews for Hyoscyamine

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Lack of side effects 
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Lack of side effects
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shayna is a member of the Pharmacy Reviewer forum
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Useful for IBS-D symptoms

When after years my Bentyl stopped working to control my IBS-D symptoms, my family doctor prescribed Levsin. I really like its form factor, because it is a sublingual tablet. It works pretty fast -- what I like best about this is if I am in public, I can reach in my purse and take this without even any water. Relief comes fairly quickly, if I can catch a flareup in its early stages.

I don't think I noticed any side effects -- sometimes it is hard to decide whether to attribute a side effect to the medicine or to the disease it is treating.

The only drawback I can think of to this medicine is it is not exceedingly strong -- I had to switch to something stronger after a few years, but again, that might be because I was not using it at the first sign of a flareup (or as prescribed as this can be used prophylactically as well).

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