Advil (Ibuprofen)

 
4.3 (1)
  (for Advil)
Advil is one brand name of the medicine also known by its generic name Ibuprofen. This page displays only reviews left by users of Advil. Click here to see all reviews left for all forms of Ibuprofen. You can also choose other review combinations.

More about Ibuprofen

What is/are Ibuprofen?

Ibuprofen (INN) (/ˈaɪbjuːproʊfɛn/ or /aɪbjuːˈproʊfən/ EYE-bew-PROH-fən; from iso-butyl-propanoic-phenolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and against swelling.

Ibuprofen has an antiplatelet effect, though relatively mild and somewhat short-lived compared with aspirin or prescription antiplatelet drugs. In general, ibuprofen also has a vasodilation effect. Ibuprofen is a 'core' medicine in the World Health Organization's Model List of Essential Medicines necessary to meet the minimum medical needs of a basic healthcare system. Ibuprofen was derived from propanoic acid by the research arm of Boots Group during the 1960s and patented in 1961. Originally marketed as Brufen, ibuprofen is available under a variety of popular trademarks, including Motrin, Nurofen, Advil, and Nuprin. Generic formulations are available as well.

Generic Motrin (IBUPROFEN) is a pain reliever and fever reducer. Temporarily relieves minor aches and pains due to: headache, muscular aches, toothache, minor pain of arthritis, backache, the common cold, menstrual cramps. Temporarily reduces fever.

Medical uses

Ibuprofen is used primarily for fever, pain, dysmenorrhea and inflammatory diseases such as rheumatoid arthritis. It is also used for pericarditis and patent ductus arteriosus

Adverse effects

Common adverse effects include: nausea, dyspepsia, gastrointestinal ulceration/bleeding, raised liver enzymes, diarrhea, constipation, epistaxis, headache, dizziness, rash, salt and fluid retention, and hypertension. A study from 2010 has shown regular use of NSAIDs was associated with an increase in hearing loss.

Infrequent adverse effects include: esophageal ulceration, heart failure, hyperkalemia, renal impairment, confusion, and bronchospasm. Ibuprofen can exacerbate asthma, sometimes fatally.

Ibuprofen appears to have the lowest incidence of digestive adverse drug reactions of all the nonselective NSAIDs. However, this holds true only at lower doses of ibuprofen, so over-the-counter (OTC) preparations of ibuprofen are, in general, labeled to advise a maximum daily dose of 1,200 mg.

Ibuprofen may be quantitated in blood, plasma, or serum to demonstrate the presence of the drug in a person having experienced an anaphylactic reaction, confirm a diagnosis of poisoning in hospitalized patients, or assist in a medicolegal death investigation. A nomogram relating ibuprofen plasma concentration, time since ingestion, and risk of developing renal toxicity in overdose patients has been published.

Mechanism of action

Nonsteroidal anti-inflammatory drugs such as ibuprofen work by inhibiting the enzyme cyclooxygenase (COX), which converts arachidonic acid to prostaglandin H2 (PGH2). PGH2, in turn, is converted by other enzymes to several other prostaglandins (which are mediators of pain, inflammation, and fever) and to thromboxane A2 (which stimulates platelet aggregation, leading to the formation of blood clots).

Like acetaminophen and indomethacin,[citation needed] ibuprofen is a nonselective COX inhibitor, in that it inhibits two isoforms of cyclooxygenase, COX-1 and COX-2. The analgesic, antipyretic, and anti-inflammatory activity of NSAIDs appears to operate mainly through inhibition of COX-2, whereas inhibition of COX-1 would be responsible for unwanted effects on the gastrointestinal tract. However, the role of the individual COX isoforms in the analgesic, anti-inflammatory, and gastric damage effects of NSAIDs is uncertain and different compounds cause different degrees of analgesia and gastric damage.

To achieve the beneficial effects of ibuprofen and other NSAIDs without gastrointestinal ulceration and bleeding, selective COX-2 inhibitors were developed to inhibit the COX-2 isoform without inhibition of COX-1.

This article uses material from the Wikipedia article Ibuprofen, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

Medicine Photos

Hover or click on a photo to enlarge it.

Medicine containing Ibuprofen

This page uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the page and product and does not endorse or recommend this or any other product.

Reviews for Advil (Ibuprofen)

See reviews for a different combination of brand names and medical conditions:
     

1 reviews

Overall rating
 
4.3
Overall satisfaction
 
4.5(1)
Efficacy
 
5.0(1)
Lack of side effects
 
3.5(1)
Already have an account?
Ratings
Overall satisfaction
Efficacy
Lack of side effects
Relevant Brand Name and Medical Condition
Additional Information
Please tell us about your experience with this medicine
Overall rating
 
4.3
Overall satisfaction
 
4.5
Efficacy
 
5.0
Lack of side effects
 
3.5
Guard Your Stomach with Ibuprofen

When Advil became available OTC I frequently took it for headaches, sinus pain, muscle aches and many types of pain, like menstrual cramps. It was very effective at that time.

However, I guess my stomach wasn't meant for all that Advil because I developed problems with taking it or any medicine in that same class - Even tho I always ate food with it and tried to protect myself from any negative effects. I had terrible reflux, heartburn, and my stomach began to hurt for several days if I took even one regular dose. I totally stopped taking it for several years because of this.

Now I take the Enteric Coated form my doctor prescribes (also has something in it to soothe my stomach) and don't have the problems with reflux or days of stomach pain that I did when taking the regular OTC type Advil. I would recommend people take the enteric coated form of this med so they won't develop problems with their stomach, because it is a common problem with NSAIDS like Advil (ibuprofen).

Relevant Brand Name and Medical Condition

Brand Name
Advil
Medical Condition
Pain

Additional Information

How long have you taken this medicine for?
More than 2 years
Report this review Comments (0) | Was this review helpful? 0 0