Isoxsuprine

 
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What is/are Isoxsuprine?

Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator in humans (under the trade name Duvadilan) and equines. Isoxsuprine is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle via beta-2 receptors.

Medical uses

Isoxsuprine it is used in humans for treatment of premature labour, i.e. a tocolytic, and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud's phenomenon, and other conditions.

Adverse effects

oxsuprine may increase the animal's heart rate, cause changes in blood pressure, and irritate the GI tract. It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and anesthetic drugs. Because it is a vasodilator, it should not be used in horses that are bleeding, or in mares following foaling.

Isoxsuprine is a prohibited class B drug in FEI-regulated competition, and is often prohibited by other equine associations. It may be detected in the urine for several weeks or months following administration. It is therefore important to check the drug-rules within an animal's given competitive organization, before administering the drug.

This article uses material from the Wikipedia article Isoxsuprine, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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