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More about Ketoprofen

What is/are Ketoprofen?

Ketoprofen, (RS)2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin.

Medical uses

Ketoprofen should not be used in combination with other NSAIDs or corticosteroids, as this increases the risk of gastrointestinal (GI) ulceration. It should also be used with caution with other anticoagulants. It is commonly used with omeprazole, sucralfate, and cimetidine to help protect the GI tract.

Adverse effects

Get emergency medical help if you have any of these signs of an allergic reaction while taking ketoprofen: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking ketoprofen and seek medical attention or call your doctor at once if you have any of these serious side effects:

  •     chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
  •     black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  •     confusion, tremors or shaking;
  •     urinating less than usual or not at all;
  •     nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  •     fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  •     bruising, severe tingling, numbness, pain, muscle weakness.

Less serious side effects of ketoprofen may include:

  •     upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas;
  •     dizziness, headache, nervousness;
  •     skin itching or rash;
  •     dry mouth;
  •     increased sweating, runny nose;
  •     blurred vision; or
  •     ringing in your ears.

Mechanism of action

Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums.

Ketoprofen topical plasters are being extensively used for treatment of musculoskeletal pain. The plasters have been shown to provide rapid and sustained delivery to underlying tissues without significantly increasing levels of drug concentration in the blood when compared to the traditional oral administration. Ketoprofen undergoes metabolism in the liver via conjugation with glucoronic acid, CYP3A4 and CYP2C9 hydroxylation of the benzoyl ring, and reduction of its keto function. Ketoprofen is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly, which decreases production of proinflammatory prostaglandin precursors.

Ketoprofen can also be used for treatment of some pain, especially nerve pain such as sciatica, postherpetic neuralgia and referred pain for radiculopathy, in the form of a cream, ointment, liquid, spray, or gel, which may also contain ketamine and lidocaine, along with other agents which may be useful, such as cyclobenzaprine, amitryptiline, acyclovir, gabapentin, orphenadrine and other drugs used as NSAIDs or adjuvant, atypical or potentiators for pain treatment.

This article uses material from the Wikipedia article Ketoprofen, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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