Labetalolum (Labetalol)

 
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Labetalolum is one brand name of the medicine also known by its generic name Labetalol. This page displays only reviews left by users of Labetalolum. Click here to see all reviews left for all forms of Labetalol. You can also choose other review combinations.

More about Labetalol

What is/are Labetalol?

Labetalol (Normodyne, Trandate) is a mixed alpha/beta adrenergic antagonist, which is used to treat high blood pressure.

Adverse effects

Side effects may include:

  •     Drowsiness
  •     Fatigue
  •     Weakness
  •     Difficulty sleeping
  •     Diminished sexual function
  •     Orthostatic hypotension (due to alpha receptor blockade)
  •     Scalp tingling
  •     Drug eruption similar to lichen planus
  •     A rare but potentially lethal side effect is respiratory distress.

Mechanism of action

Labetalol combines both selective, competitive, alpha-1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. In man, the ratios of alpha- to beta- blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenous (IV) administration, respectively. The principal physiologic action of labetalol is to competitively block adrenergic stimulation of β-receptors within the myocardium (β1-receptors) and within bronchial and vascular smooth muscle (β2-receptors), and α1-receptors within vascular smooth muscle. This causes a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined α- and β-adrenergic blocking activity.

This article uses material from the Wikipedia article Labetalol, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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Medicine containing Trandate

Medicine containing Labetalol

This page uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the page and product and does not endorse or recommend this or any other product.

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