Meloxicam

 
3.2 (4)
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More about Meloxicam

What is/are Meloxicam?

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and fever reducer effects. It is a derivative of oxicam, closely related to piroxicam, and falls in the enolic acid group of NSAIDs. It was developed by Boehringer-Ingelheim. Meloxicam starts to relieve pain 30–60 minutes after administration.

Medical uses

Meloxicam is also used in the veterinary field, most commonly in dogs and cats, but also sees off-label use in other animals such as cattle and exotics. The U.S. Food and Drug Administration sent a Notice of Violation to the manufacturer for its promotional materials which included promotion of the drug for off-label use. In the U.S. the drug is indicated for management of pain and inflammation associated with osteoarthritis in dogs only. In Europe, where the product has been available since the early 1990s[citation needed], it is also prescribed and licensed for other anti-inflammatory benefits including relief from both acute and chronic pain in dogs. Side effects in animals are similar to those found in humans; the principal side effect is gastrointestinal irritation (vomiting, diarrhea and ulceration). Rarer but important side effects include liver and kidney toxicity.

Since 2003, the oral (liquid) formulations of meloxicam have been licensed in the U.S for use in dogs only, with the January 2005 product insert specifically warning in bold-face type: "Do not use in cats."An injectable formulation for use in dogs was approved by the FDA in November 2003, with a formulation for cats, for surgical use only, approved in October 2004.

In the U.S., per the manufacturer's clinical instructions as of July 2010, injectable meloxicam is indicated in operative use with felines as a single, one-time dose only, with specific and repeated warnings not to administer a second dose. In June 2007, a new oral version of meloxicam was licensed in Europe for the long-term relief of pain in cats. As of June 2008, meloxicam is registered for long term use in cats in Australia, New Zealand, and throughout Europe.

Adverse effects

Meloxicam use can result in gastrointestinal toxicity and bleeding, tinnitus, blinding headaches, rash, and very dark or black stool (a sign of intestinal bleeding). It has fewer gastrointestinal side effects than diclofenac, piroxicam, naproxen, and perhaps all other NSAIDs which are not COX-2 selective. Although meloxicam does inhibit thromboxane A, it does not appear to do so at levels that would interfere with platelet function.

Mechanism of action

Meloxicam inhibits cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2—the first step in the synthesis of prostaglandins, which are mediators of inflammation. Meloxicam has been shown, especially at its low therapeutic dose, selectively to inhibit COX-2 over COX-1.

Meloxicam concentrations in synovial fluid range from 40% to 50% of those in plasma. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid as compared to plasma. The significance of this penetration is unknown, but it may account for the fact that it performs exceptionally well in treatment of arthritis in animal models.

This article uses material from the Wikipedia article Meloxicam, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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Medicine containing Mobic

Medicine containing Meloxicam

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Reviews for Meloxicam

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4 reviews

Overall rating
 
3.2
Overall satisfaction
 
3.1(4)
Efficacy
 
3.1(4)
Lack of side effects
 
3.4(4)
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Overall rating
 
4.7
Overall satisfaction
 
5.0
Efficacy
 
4.5
Lack of side effects
 
4.5
This drug has helped tremendously

Basal cell arthritis in thumbs and thumb joint areas, this drug has helped tremendously. I am off of it temporarily per MD orders, to see difference and I believe I need to go back to it as pain has recurred without it

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Brand Name
Mobic
Medical Condition
Rheumatoid Arthritis

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How long have you taken this medicine for?
1 month - 6 months
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Overall rating
 
1.0
Overall satisfaction
 
0.5
Efficacy
 
1.5
Lack of side effects
 
1.0
Developed ulcers

developed ulcers and had to have my gall bladder removed therefore i no longer take this medication

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Brand Name
Mobic
Medical Condition
Rheumatoid Arthritis

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How long have you taken this medicine for?
0-1 months
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Overall rating
 
3.5
Overall satisfaction
 
4.0
Efficacy
 
3.5
Lack of side effects
 
3.0
Mobic worked VERY WELL

Mobic worked VERY WELL in helping to relieve the joint pain, but after taking the drug for 3 weeks I started breaking out with hives and had to stop taking it.

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Brand Name
Mobic
Medical Condition
Rheumatoid Arthritis

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How long have you taken this medicine for?
1 month - 6 months
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Overall rating
 
3.7
Overall satisfaction
 
3.0
Efficacy
 
3.0
Lack of side effects
 
5.0
darwin is a member of the Pharmacy Reviewer forum
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Meloxicam for Oestoarthritis

I am currently taking meloxicam for osteoarthritis. I don't have a long history with this drug, but I've taken it long enough to know a bit about its efficacy. My dosage is 7.5 mg once a day.

All things considered, meloxicam has been a good drug for me. I suffer with daily aches and pains around my body, and some days/weeks/months I can have arthritic flares that are extremely painful. I've taken Ibuprofen for many years to fight my pain, and also used aspirin. My doctor and I talked about using a different pain reliever/anti-inflammatory since I need something daily long-term. As far as that goes, it's wonderful to take one little pill once a day.

I've also found this drug to be without adverse reactions. I've had no side effects to date. Meloxicam is easy on my tummy and doesn't give me any dizziness or drowsiness.

I think that the first 10-12 hours this drug works well. Or as well as I could expect for a non-narcotic med. Does meloxicam last a full 24 hours? No. I think it's fair to compare this drug with 800 mg Ibuprofen. Over the short haul, 800 mg Ibuprofen knocks moderate pain out of the park, for me. It's the best. Meloxicam comes close, but is not as good as a scripted dose of Ibuprofen.

I've been advised to take acetaminophen with meloxicam for added pain relief, which I've done on a few occasions. I don't think the acetaminophen helps, so I've discontinued adding it.

The thing I dislike the most about meloxicam is that if I get a headache, there's nothing else I can take. Adding another NSAID is not a good idea, and acetaminophen doesn't work well for me. I've had a stubborn headache since I began taking meloxicam, and I was stuck with it.

I know I'm looking for the perfect anti-inflammatory/pain reliever for my aching joints; I had high hopes for meloxicam when my doctor prescribed it. I will continue to take the med because it does help on a basic level. I didn't take it for a few days to see what the difference would be, and there was a measurable difference. It's fair to say that if my pain is a six, meloxicam can take it down to a three or four.

The best measure of this drug's success would be an arthritic flare. Fortunately, I haven't had one in awhile. If I do, that would be the best way to see how effective meloxicam is. (Or it could be that I haven't had a flare because meloxicam is doing its job. That's a positive way to look at it!) If you suffer with chronic joint pain, I recommend you try meloxicam. Some people say this med gets rid of their pain completely. I wouldn't say that, but meloxicam makes enough of a difference for me to continue taking it.

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Medical Condition
Osteoarthritis

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How long have you taken this medicine for?
1 month - 6 months
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