Salofalk (Mesalazine)

 
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Salofalk is one brand name of the medicine also known by its generic name Mesalazine. This page displays only reviews left by users of Salofalk. Click here to see all reviews left for all forms of Mesalazine. You can also choose other review combinations.

More about Mesalazine

What is/are Mesalazine?

Mesalazine (INN, BAN), also known as mesalamine (USAN) or 5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug used to treat inflammatory bowel disease, such as ulcerative colitis. and mild-to-moderate Crohn's disease. Mesalazine is a bowel-specific aminosalicylate drug that acts locally in the gut and has its predominant actions there, thereby having few systemic side effects.

As a derivative of salicylic acid, mesalazine is also thought to be an antioxidant that traps free radicals, which are potentially damaging byproducts of metabolism. Mesalazine is the active moiety of sulfasalazine, which is metabolized to sulfapyridine and mesalazine.

Adverse effects

Commonly:

    Diarrhea
    Nausea
    Cramping
    Flatulence

Uncommonly:

    Headache
    Exacerbation of the colitis
    Hypersensitivity reactions (including rash, urticaria aka hives, interstitial nephritis and lupus erythematosus-like syndrome)
    Hair loss

Rarely:

    Acute pancreatitis
    Hepatitis
    Nephrotic syndrome
    Blood disorders (including agranulocytosis, aplastic anaemia, leukopenia, neutropenia, thrombocytopenia)
    Fever

Mesalazine avoids the sulfonamide side effects of sulfasalazine (which contains additional sulfapyridine), but carries additional rare risks of:

    Allergic lung reactions
    Allergic myocarditis
    Methaemoglobinaemia

This article uses material from the Wikipedia article Mesalazine, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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