What is/are Nafarelin?
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin may be used in the treatment of estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat central precocious puberty, and to control ovarian stimulation in IVF. It is normally delivered via a nasal spray. Nafarelin acetate is marketed by Searle (now part of Pfizer) under the brand name Synarel.
Abatacept is currently approved for use in people with rheumatoid arthritis who have had an inadequate response to one or more DMARDs. It is useful in delaying the progression of structural damage and reducing symptoms of rheumatoid arthritis. However, it should not be used in combination with anakinra or TNF antagonists.
Side effects of nafarelin are mostly related to the low estrogen state. Side effects include hot flashes, vaginal dryness, headaches, mood changes, and decreased interest in sex. Some patients may experience acne, muscle pain, reduced breast size, and irritation of the tissue inside the nose. These side effects should disappear after stopping the medication.
- Heavy or continued menstrual bleeding;
- Pelvic pain or swelling;
- Increased thirst, increased urination;
- Seizure (convulsions);
- Chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- Sudden numbness or weakness, sudden severe headache, confusion, problems with vision, speech, or balance; or
- Nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- Changes in breast size;
- Oily skin or acne, increased body odor;
- Increase in pubic hair growth;
- Mood changes;
- Runny nose;
- Hot flashes;
- Mild headache, muscle pain;
- Light and occasional menstrual bleeding;
- White or brownish vaginal discharge;
- Vaginal dryness; or
- Changes in sexual desire.
This article uses material from the Wikipedia article Nafarelin, which is released under the Creative Commons Attribution-Share-Alike License 3.0.