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More about Naphazoline

What is/are Naphazoline?

Naphazoline (in the hydrochloride form) is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in several over-the-counter formulations including Clear Eyes and Naphcon eye drops. It has the molecular formula C14H14N2.HCl and a molecular weight of 246.73 g/mol.

Medical uses

  •     Hypersensitivity to naphazoline
  •     Patients taking MAO inhibitors can experience a severe hypertensive crisis if given a sympathomimetic drug such as naphazoline HCl
  •     Use in infants and children can result in central nervous system depression, leading to coma and marked reduction in body temperature
  •     Should be used with caution in patients with severe cardiovascular disease including cardiac arrhythmia and in patients with diabetes, especially those with a tendency toward diabetic ketoacidosis
  •     Drug interactions can occur with anaesthetics that sensitize the myocardium to sympathomimetics (e.g. cyclopropane or halothane cautiously)
  •     Exercise caution when applying prior to use of phenylephrine.
  •     Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion.

A possible association with stroke has been suggested.

Adverse effects

Top using naphazoline ophthalmic and call your doctor at once if you have:

  •     Ongoing or worsening eye redness;
  •     Eye pain;
  •     Changes in your vision;
  •     Chest pain, fast or uneven heart rate; or
  •     Severe headache, buzzing in your ears, anxiety, confusion, or feeling short of breath.

Common side effects may include:

  •     Mild burning or stinging of the eye;
  •     Blurred vision, watery eyes; or
  •     Mild headache, dizziness, nervousness.

This article uses material from the Wikipedia article Naphazoline, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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