Oxycodone

 
3.9 (7)
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More about Oxycodone

What is/are Oxycodone?

Oxycodone is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic generally indicated for relief of moderate to severe pain. It was developed in 1916 in Germany as one of several new semi-synthetic opioids in an attempt to improve on the existing opioids.

Oxycodone is available as single ingredient medication in immediate release and controlled release. Combination products formulated with non-narcotic ingredients such as NSAIDs and paracetamol are also available as immediate release formulation.

Medical uses

Oxycodone has been in clinical use since 1917. and it is used for managing moderate to moderately severe acute or chronic pain.It has been found to improve quality of life for those with many types of pain.

Controlled release oral tablet form is indicated for cancer and other chronic pains and intended to be taken every 12 hours. Immediate release forms are used more commonly for management of moderate pain. An Italian study concluded from investigating multiple studies that controlled release oxycodone is comparable to instant release oxycodone, morphine and hydromorphone in management of moderate to severe cancer pain. It indicated that side effect appears to be lesser than morphine and that it is a valid alternative to morphine and a first-line treatment for cancer pain.

In 2001, the European Association for Palliative Care recommended that oral oxycodone could be taken as a second-line alternative to oral morphine for cancer pain.

Administration

Oxycodone can be administered by parenteral or oral route.

Dosage

Starting dose of 5–15 mg oral every 4 to 6 hours or 10 mg controlled release every 12 hours.

Maintenance dose of 10–30 mg every 4 hours or 20–640 mg controlled release form oxycodone per day for cancer pain with indication to use immediate release tablets as needed for break-through pain.

Adverse effects

Common side effects include constipation, fatigue, dizziness, nausea, vomiting, dry mouth, anxiety, itching, and sweating.Less common side effects (experienced by less than 5% of patients) include loss of appetite, nervousness, abdominal pain, diarrhea, urine retention, dyspnea, and hiccups,

In high doses, overdoses, or in patients not tolerant to opiates, oxycodone can cause shallow breathing, bradycardia, cold-clammy skin, apnea, hypotension, miosis, circulatory collapse, respiratory arrest, and death.

Dependence, addiction and withdrawal

The risk of experiencing severe withdrawal symptoms is high if a patient has become physically dependent or addicted and discontinues oxycodone abruptly. Therefore, particularly in cases where the drug has been taken regularly over an extended period of time, use should be discontinued gradually rather than abruptly. People who use oxycodone in a recreational, hazardous, or harmful fashion (not as intended by the prescribing physician) are at even higher risk of severe withdrawal symptoms, as they tend to use higher-than-prescribed doses. The symptoms of oxycodone withdrawal are the same as for other opiate-based painkillers, and may include "anxiety, panic attack, nausea, insomnia, muscle pain, muscle weakness, fevers, and other flu-like symptoms".

Withdrawal symptoms have also been reported in newborns whose mothers had been either injecting or orally taking oxycodone during pregnancy.

Detection in biological fluids

Oxycodone and/or its major metabolites may be measured in blood or urine to monitor for clearance, abuse, confirm a diagnosis of poisoning, or assist in a medicolegal death investigation. Many commercial opiate screening tests cross-react appreciably with oxycodone and its metabolites, but chromatographic techniques can easily distinguish oxycodone from other opiates.

Mechanism of action

In 1997, a group of Australian researchers proposed (based on a study in rats) that oxycodone acts on κ-opioid receptors, unlike morphine, which acts upon μ-opioid receptors. Further research by this group indicated the drug appears to be a κ2b-opioid agonist. However, this conclusion has been disputed, primarily on the basis that oxycodone produces effects that are typical of μ-opioid agonists, mainly because oxycodone is metabolized in the liver to oxymorphone as a metabolite, which is a more potent opioid agonist with stronger/higher binding affinity to μ-opioid receptors compared to oxycodone.

In 2006, research by a Japanese group suggested the effect of oxycodone is mediated by different receptors in different situations. Specifically in diabetic mice, the κ-opioid receptor appears to be involved in the antinociceptive effects of oxycodone, while in nondiabetic mice, the μ1-opioid receptor seems to be primarily responsible for these effects.

This article uses material from the Wikipedia article Oxycodone, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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Medicine containing OxyContin

Medicine containing Oxycodone

This page uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the page and product and does not endorse or recommend this or any other product.

Reviews for Oxycodone

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7 reviews

 
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3.9
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4.2  (7)
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4.0  (7)
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3.4  (7)
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Please tell us about your experience with this medicine
sad story

i got into a motorcylce accident in 2011, been hooked on blue 30s ever since. i have since spent all the money ive had obtaining them through other means when i run out because my doc refuses me any more than 30 a month and 1 a day wont last. i am depressed and about to lose my job. can anyone help

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How long have you taken this medicine for?
More than 2 years
F
firas
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Oxycodone is the only thing that works

This has been the only medication that stopped the migraines that started when I started chemo for breast cancer. I initially refused to continue the chemo because my migraines were so severe but I was assigned a palliative care pain management doctor who prescribed 30mg oxycodone pills for me. They got me through the chemo and radiation but my headaches did not stop when the treatments did. I took them for 10 years to controll my migraines so I could just function like a normal person. Two years my pain management doctor dismissed me saying I was her worst failure as a patient because I did not die. She cared nothing that my intense migraines still continued. It is not possible to get a prescription for oxycodone in NJ, it is not legal. Are there any online pharmacies of pharmacies from other countries that are legitimate and sell this medication. I am thinking about drinking anti freeze to end my life just to be free from this constant pain.

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How long have you taken this medicine for?
More than 2 years
S
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Absolutely nothing

I spent years fighting workers' comp to get approval for the one drug that relieved my pain Oxycintin OC now its been replaced by a new formoula that does absolutely nothing for and my pain has returned with a vengence. Thanks for nothing prudue you have made life unbearable again. please bring back the OC!

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Brand Name
OxyContin
Medical Condition
Pain

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How long have you taken this medicine for?
6 months - 2 years
Reviewed anonymously by a forum member
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My experience has been good

my experience has been good. due to the chronic pain i have been in due to a severe back condition.

Relevant Brand Name and Medical Condition

Brand Name
OxyContin
Medical Condition
Pain

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How long have you taken this medicine for?
More than 2 years
Reviewed anonymously by a forum member
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Helps my daily life style

I have tore up my left knee,right knee shot no knees period,hips are gone,osteo arthritis,severe pain. oxycodone helps me manage my severe pain,helps my daily life style.

Relevant Brand Name and Medical Condition

Brand Name
OxyContin
Medical Condition
Pain

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How long have you taken this medicine for?
More than 2 years
Reviewed anonymously by a forum member
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It was very effective

Used as a temporary (less than three weeks), one pill, twice a day, as relief from a multi-bone ankle surgery recovery post severe trauma (bimalleolar tib/fib fracture). It was very effective as a pain reliever as the general anesthesia (nerve block-lasting 24 hrs post ortho-surgery)wore off.

Relevant Brand Name and Medical Condition

Brand Name
OxyContin
Medical Condition
Pain

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How long have you taken this medicine for?
0-1 months
Reviewed anonymously by a forum member
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ShamedSandy is a member of the Pharmacy Reviewer forum
Total Posts: 216
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Effective pain med

I've taken 5 mgs oxycodone in the form of Percocet for the past 3 months. It is effective for my pain, but I have a great deal of pain so I wish I were scripted a little more. I was given 90 pills last month, told my pain management doctor I needed more help, and she gave me 120 pills this month so I could take extra if I needed to. That helps a bit but now I worry about the Tylenol in the pills as I cannot seem to remember not to take Tylenol if I have a headache or not to take cold medicine with Tylenol in it! At first I experienced a lot of itchiness with this medicine, but that went away gradually. I also experience headaches first thing in the morning that subside when I take my medicine. I'm aware I'm probably habituated to this medicine now, but as I do not feel euphoric from it I see no reason to abuse it or continue taking it after my pain issue is dealt with. It doesn't feel like a "fun drug" to me. I also have a little constipation, but nothing too serious. Instead of going every day, I go every few days, that's all. The medicine also gives me warm flushes upon onset and it causes me to have little to no appetite. I've lost ten pounds since starting it and that's not a bad thing in my opinion!!!

All in all, a very useful medicine with few side effects for me. I hope to be able to taper off slowly when I need to and suffer very few withdrawal symptoms.

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How long have you taken this medicine for?
1 month - 6 months
S
(Updated: January 28, 2014)
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