3.8 (1)
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More about Pantoprazole

What is/are Pantoprazole?

Pantoprazole (sold under various brand names including Somac, Tecta, Pantoloc, Controloc, Pansiv, Protium, Protonix, Pantecta, Pantoheal, Pantpas, Ppi-40, and Neoppi) is a proton pump inhibitor drug that inhibits gastric acid secretion.

Medical uses

Pantoprazole is used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary.[citation needed] It can be used as a maintenance therapy for long term use after initial response is obtained.

This medication may affect the results of certain lab tests, such as drug screenings (pantoprazole can cause a false positive for THC, the psychoactive component of cannabis).

Common uses

This medicine is a proton pump inhibitor (PPI) used to treat ulcers, gastroesophageal reflux disease (GERD), erosive esophagitis, or Zollinger-Ellison syndrome. This medicine works by blocking acid production in the stomach. It may be used in combination with antibiotics including amoxicillin or clarithromycin to treat certain types of ulcers. It may also be used to treat other conditions as determined by your doctor.

Before using

Additional monitoring of your dose or condition may be needed if you are taking itraconazole, ketoconazole, or voriconazole. Do not start or stop any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.


Follow the directions for using this medicine provided by your doctor. Swallow whole. Do not break, crush, or chew before swallowing. This medicine may be taken with antacids if your doctor has instructed you to take antacids. Do not miss any doses. Store this medicine at room temperature, away from heat and light.

For best results, continue taking this medicine for the full course of treatment even if you feel better in a few days. If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Adverse effects

Antacid preparations such as pantoprazole work by suppressing the acid-mediated breakdown of proteins. This leads to an elevated risk of developing food and drug allergies due to undigested proteins passing into the gastrointestinal tract where sensitisation occurs. It is unclear whether this risk occurs with short-term or only long-term use.


  •     Gastrointestinal: Abdominal pain (3%), diarrhea (4%), flatulence (4%)
  •     Neurologic: Headache (5%)


  •     Gastrointestinal: Atrophic gastritis, clostridium difficile diarrhea
  •     Hematologic: Thrombocytopenia (less than 1%)
  •     Immunologic: Stevens-Johnson syndrome, toxic epidermal necrolysis
  •     Musculoskeletal: Muscle disorders, bone fracture and infection, Clostridium difficile, osteoporosis-related, hip fracture, rhabdomyolysis
  •     Renal: Interstitial nephritis (rare)
  •     Nutrition: May reduce the absorption of important nutrients, vitamins and minerals, as well as medications, leaving users at increased risk for pneumonia [Dr. John Cooke, chair of Methodist Hospital's cardiovascular services] [Houston Chronicle Health Zone dated Thursday, July 11, 2013] (Journal: Circulation)
  •     Cardiovascular: Increase in a chemical that suppresses the production of nitric oxide by 25% in humans, which have proven to relax and protect arteries and veins. Causes blood vessels to constrict, a development that could lead to a number of cardiovascular problems if continued for a prolonged period of time. [Dr. John Cooke, chair of Methodist Hospital's cardiovascular services] [Houston Chronicle Health Zone dated Thursday, July 11, 2013] (Journal: Circulation)


If your symptoms do not improve or if they become worse, check with your doctor. Keep all doctor and laboratory appointments while you are using this medicine. This medicine may affect the results of certain lab tests (e.g., false positive urine screen for thc). Make sure laboratory personnel and your doctors know you use this medicine. Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist.

For women: if you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is unknown if this medicine is excreted in breast milk. If you are or will be breast-feeding while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects

Side effects, that may go away during treatment, include headache, dizziness, diarrhea, or nausea. If they continue or are bothersome, check with your doctor. Contact your doctor immediately if you experience swelling of hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; hoarseness; or rash. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

If you take too much

If overdose is suspected, contact your local poison control center or emergency room immediately.

Additional information

If you are taking this medicine for gastric ulcers or reflux disease, your symptoms should improve within 4 to 8 weeks. If your symptoms do not improve or if they become worse, contact your doctor.

Do not share this medicine with others for whom it was not prescribed. Do not use this medicine for other health conditions. Keep this medicine out of the reach of children and pets. If using this medicine for an extended period of time, obtain refills before your supply runs out.

Drug interactions

Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking.


This article uses material from the Wikipedia article Pantoprazole, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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Medicine containing Protonix

Medicine containing Pantoprazole

This page uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the page and product and does not endorse or recommend this or any other product.

Reviews for Pantoprazole

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1 reviews

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3.5  (1)
3.5  (1)
Lack of side effects 
4.5  (1)
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H20shed65 is a member of the Pharmacy Reviewer forum
Total Posts: 11910
Reputation: 26314
User Title: Famous PRer
Very Effective PPI

I was prescribed Protonix off and on over about two years for persistent GERD. I found this drug to be very effective when Over The Counter preparations such as Zantac stopped being effective. I took 1 40MG Tablet every morning for about 3 months which completely stopped all my GERD symptoms including heartburn, acid reflux, etc. within 72 hours. I personally found no side effects whatever when on this medication.

PROS: Effective, Easy Once a Day Dosing, no noticeable side effects

CONS: Not Available Generically When I took this Medication, but may be now.

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