Neo-Synephrine Ophthalmic (Phenylephrine Ophthalmic)

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Neo-Synephrine Ophthalmic is one brand name of the medicine also known by its generic name Phenylephrine Ophthalmic. This page displays only reviews left by users of Neo-Synephrine Ophthalmic. Click here to see all reviews left for all forms of Phenylephrine Ophthalmic. You can also choose other review combinations.

More about Phenylephrine Ophthalmic

What is/are Phenylephrine Ophthalmic?

Phenylephrine is a selective α1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine is marketed as a substitute for the decongestant pseudoephedrine, though clinical studies differ regarding phenylephrine's effectiveness in this role.

Medical uses


Phenylephrine is used as a decongestant sold as an oral medicine, as a nasal spray, or as eye drops. Phenylephrine is now the most common over-the-counter decongestant in the United States; oxymetazoline is a more common nasal spray.

Oral phenylephrine is extensively metabolised by monoamine oxidase, an enzyme that is present in the intestinal wall and in the liver. Compared to intravenous pseudoephedrine, it has a reduced and variable bioavailability; only up to 38%.Because phenylephrine is a direct selective α-adrenergic receptor agonist, it does not cause the release of endogenous noradrenaline, as pseudoephedrine does. Both pseudoephedrine and phenylephrine are likely to cause side effects such as central nervous system stimulation, insomnia, anxiety, irritability, and restlessness. Unlike pseudoephedrine, phenylephrine's effectiveness as a decongestant stems from its vasoconstriction of nasal blood vessels, thereby decreasing blood flow to the sinusoidal vessels, leading to decreased mucosal edema.

As a nasal spray, phenylephrine is available in 1% and 0.5% concentrations. It causes some rebound congestion effects, similar to oxymetazoline, although possibly to a lesser degree.

Hemorrhoid discomfort

This medication is used to temporarily relieve swelling, burning, pain, and itching caused by hemorrhoids. It works by temporarily narrowing the blood vessels in the area. This effect decreases swelling and discomfort. Some products may also contain substances (e.g., cocoa butter, hard fat, mineral oil, shark liver oil) that form a protective barrier to prevent too much irritating contact with stool.


Phenylephrine is used as an eye drop to dilate the pupil in order to facilitate visualization of the retina. It is often used in combination with tropicamide as a synergist when tropicamide alone is not sufficient. Narrow-angle glaucoma is a contraindication to phenylephrine use. As a mydriatic, it is available in 2.5% and 10% minims.


Phenylephrine is commonly used as a vasopressor to increase the blood pressure in unstable patients with hypotension, especially resulting from septic shock. Such use is common in anesthesia or critical-care practices; phenylephrine is especially useful in counteracting the hypotensive effect of epidural and subarachnoid anesthetics, as well as the vasodilating effect of bacterial toxins and the inflammatory response in sepsis and systemic inflammatory response syndrome. It has the advantage of not being inotropic or chronotropic, and so it strictly elevates the blood pressure without increasing the heart rate or contractility (reflex bradycardia may result from the blood pressure increase, however). This is especially useful if the heart is already tachycardic and/or has a cardiomyopathy. The elimination half life of phenylephrine is about 2.5 to 3 hours.

Because of its vasoconstrictive effect, phenylephrine (Neo-Synephrine) can cause severe necrosis if it infiltrates the surrounding tissues. Because of this, it should be given through a central line if at all possible. Damage may be prevented or mitigated by infiltrating the tissue with the alpha blocker phentolamine by subcutaneous injection. 0.25% phenylephrine hydrochloride is used as a vasoconstrictor in some suppository formulations.


Phenylephrine is used by urologists to abort priapism. It is diluted significantly and injected directly into the corpora cavernosa. The mechanism of action is to cause constriction of the blood vessels entering into the penis thus breaking the pathophysiologic cycle that continues the priapism.

Adverse effects

The primary side effect of phenylephrine is hypertension. Patients with hypertension are typically advised to avoid products containing phenylephrine. Prostatic hyperplasia can also be symptomatically worsened by use, and chronic use can lead to rebound hyperemia.[5] Patients with a history of anxiety disease or panic disorder, or epilepsy and on anticonvulsant medication should not take this substance. The drug interaction might produce seizures. Some patients have been shown to have an upset stomach, severe abdominal cramping, and vomiting issues connected to taking this drug. Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion.

This article uses material from the Wikipedia article Phenylephrine Ophthalmic, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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