Pneumococcal conjugate vaccine

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What is/are Pneumococcal conjugate vaccine?

Pneumococcal conjugate vaccine (PCV) is a pneumococcal vaccine used to protect infants and young children against disease caused by the bacteria Streptococcus pneumoniae (pneumococcus). There are currently three PCV vaccines available on the global market: Prevnar (called Prevenar in some countries), Synflorix and Prevnar 13.

Prevnar is a heptavalent vaccine, meaning that it contains the cell membrane sugars of seven serotypes of pneumococcus, conjugated with Diphtheria proteins. It was manufactured by Wyeth. In the United States, vaccination with Prevnar is recommended for all children younger than 2 years, and for unvaccinated children between 24 and 59 months old who are at high risk for pneumococcal infections.

Synflorix is produced by GlaxoSmithKline. It is a decavalent vaccine, meaning that it contains ten serotypes of pneumococcus (1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F) which are conjugated to a carrier protein. Synflorix received a positive opinion from the European Medicines Agency for use in the European Union in January 2009  and GSK received European Commission authorization to market Synflorix in March 2009.

Prevnar 13 is produced by Pfizer. It is a tridecavalent vaccine, meaning that it contains thirteen serotypes of pneumococcus (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F) which are conjugated to a carrier protein. Prevnar 13 was approved by the U.S. Food and Drug Administration on February 24, 2010. However, the Centers for Disease Control and Prevention (CDC) has since stated that it will await the outcome of a trial under way in the Netherlands before deciding whether to recommend the drug for all adults aged 50 or older.

This article uses material from the Wikipedia article Pneumococcal conjugate vaccine, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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