Promethazine

 
4.8 (3)
This page displays reviews written by users of all forms of Promethazine. You can also choose to see reviews only for a specific medical condition or brand name.

More about Promethazine

What is/are Promethazine?

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties. In some countries it is prescribed for insomnia when benzodiazepines are contraindicated. It is available in many countries under the brand names Phenergan, Promethegan, Romergan, Fargan, Farganesse, Prothiazine, Avomine, Atosil, Receptozine, Lergigan, and (in the UK) Sominex.

Medical uses

  •     As a sedative
  •     For preoperative sedation and to counteract postnarcotic nausea
  •     To reduce nervousness, restlessness and agitation caused by psychiatric conditions (used for this purpose mainly in Europe)
  •     As antiallergic medication to combat hay fever (allergic rhinitis), etc., or to treat allergic reactions, alone or in combination with oral decongestants such as pseudoephedrine
  •     As an adjunct treatment for anaphylactoid conditions (IM/IV route preferred)
  •     Together with codeine or dextromethorphan against cough
  •     As a motion sickness or seasickness remedy when used with ephedrine or pseudoephedrine
  •     To combat moderate to severe morning sickness and hyperemesis gravidarum: In the UK, promethazine is drug of first choice, being preferred as an older drug with which there is a greater experience of use in pregnancy (second in line being metoclopramide or prochlorperazine)
  •     Previously, it was used as an antipsychotic,[6] although it is generally not administered for this purpose now; promethazine has only approximately 1/10 of the antipsychotic strength of chlorpromazine.
  •     Also, it is used to potentiate any opiates, commonly combined with pethidine (meperidine, or Demerol) in a brand called Mepergan, a meperidine/promethazine combination. It is frequently used in conjunction with codeine, in a syrup form. The combination leads to more powerful euphoric effects than with codeine alone.
  •     Treatment for migraines

Adverse effects

Some common side effects include:

  •     Tardive dyskinesia
  •     Confusion in the elderly
  •     Drowsiness, dizziness, fatigue, more rarely vertigo
  •     Dry mouth
  •     Respiratory depression in patients under age of two and in those with severely compromised pulmonary function
  •     Constipation
  •     Chest discomfort/pressure (typically in cases when patient is already taking medication for high blood pressure)
  •     Euphoria (very rare, except with high IV doses and/or coadministration with opioids/CNS depressants)
  •     Akathisia [15]
  •     Paresthesia
  •     Short temper/irritability

Extremely rare side effects include:

  •     Seizures
  •     Neuroleptic malignant syndrome

Because of potential for more severe side effects, this drug is on the list to avoid in the elderly. (See NCQA’s HEDIS Measure: Use of High Risk Medications in the Elderly). In many countries (including the US and UK), promethazine is contraindicated in children less than two years of age, and strongly cautioned against in children between two and six, due to problems with respiratory depression and sleep apnoea.

This article uses material from the Wikipedia article Promethazine, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

Medicine Photos

Hover or click on a photo to enlarge it.

Medicine containing Promethazine

This page uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the page and product and does not endorse or recommend this or any other product.

Reviews for Promethazine

See reviews for a different combination of brand names and medical conditions:
     

3 reviews

Overall rating 
 
4.8
Overall satisfaction 
 
5.0  (3)
Efficacy  
 
5.0  (3)
Lack of side effects 
 
4.3  (3)
Already have an account?
Ratings
Overall satisfaction
Efficacy
Lack of side effects
Relevant Brand Name and Medical Condition
Additional Information
Please tell us about your experience with this medicine
Phenergan treats nausea and vomiting

Phenergan is a brand of Promethazine.
I keep this med on hand in suppository form for vomiting associated with viral GI infection (aka stomach bug)
I use it only if vomiting is persistent and I can't keep down anything by mouth (including a popsicle)
I've just found that once the stomach is empty and one is "dry heeving", it makes sense to stop those smooth muscle spasms and wait comfortably for the virus to run its course. This med causes sedation, so an added benefit is a few restful hours of sleep after which I can usually tolerate clear liquids by mouth.
Luckily, my PCP agrees with me about this and readily gives me the script to keep on hand and in the frig for "emergencies". She probably likes that I will not be calling her answering service in the middle of the night or on weekends ! :)

I'm not sure why it says that MEPERIDINE is a brand of promethazine.
AFAIK, Meperidine is the generic for Demerol, which is a sched II narcotic (although there is a combination drug which contains promethazine to curb the potential side effect of nausea)

Relevant Brand Name and Medical Condition

Brand Name
Phenergan
Medical Condition
Nausea / Vomiting

Additional Information

How long have you taken this medicine for?
More than 2 years
M
Report this review Comments (0) | Was this review helpful to you? 2 0
It worked for me

I was in the hospital for heart pains and they gave me Phenergan for nausea. It seemed to be the only thing that worked for me.

Relevant Brand Name and Medical Condition

Brand Name
Phenergan
Medical Condition
Nausea / Vomiting

Additional Information

How long have you taken this medicine for?
1 month - 6 months
Reviewed anonymously by a forum member
Report this review Comments (0) | Was this review helpful to you? 0 0
Phenergan helped me

I have been prescribed Phenergan at different times in my life for short periods of time, weeks or few months at a time. I had Phenergan prescribed for the flu, but most often doctors have prescribed Phenergan to combine with my pain medication or other medicines that nausea me (especially when I first begin taking them), such as after surgery because the anesthesia nauseates me.
I always received relief of the nausea caused by other medications from Phenergan, if I took it when the nausea began and didn't wait too late.

Fortunately, the only side effects I noticed from taking Phenergan intermittently was it potentiated or made the pain medicine have a stronger effect on me. It made me drowsy and I usually took a nap, which was exactly what I wanted while feeling so ill.

I wouldn't want to function while combining these medications and was very careful to take as directed by my physician because they can cause respiratory depression, even death, if people take too much Phenergan or any of their other medicines.

Relevant Brand Name and Medical Condition

Brand Name
Phenergan
Medical Condition
Nausea / Vomiting

Additional Information

How long have you taken this medicine for?
More than 2 years
S
Report this review Comments (0) | Was this review helpful to you? 2 0