Salmeterol/Fluticasone

 
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What is/are Salmeterol/Fluticasone?

The combination preparation fluticasone/salmeterol is a formulation containing fluticasone propionate and salmeterol xinafoate, used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is marketed by GlaxoSmithKline under various trade names including Advair (in the US and Canada), Seretide (Brazil, India, Australia, Colombia, EU, México, New Zealand, South Africa, South Korea, UK, Estonia), Viani (Germany), Adoair (Japan) and Foxair (South Africa).In India it is marketed by Intas under the trade name 'Quikhale SF'. Annual worldwide sales were approximately US$7 billion in 2009. Patent protection in the US expired in 2010, and European patent protection will expire in 2013. However, the availability of a generic form of Advair in the United States may be significantly delayed because the Food and Drug Administration has not determined a standard for the bioequivalence of inhaled steroids in multi-dose inhalers or dry powder inhalers.

Fluticasone, a corticosteroid, is the anti-inflammatory component of the combination, while salmeterol treats constriction of the airways. Together, they relieve the symptoms of coughing, wheezing and shortness of breath.

Adverse effects

The common and minor side effects of this combination are those of its individual drugs. For instance, the use of inhaled corticosteroids is associated with oral candidiasis (commonly known as Yeast Infection). It is recommended to rinse and gargle with water after inhaling the medication. This decreases the risk of developing a candidiasis infection.

Whilst the use of inhaled steroids and long acting beta-adrenoceptor agonist (LABA) are recommended in asthma guidelines for the resulting improved symptom control, concerns have been raised that salmeterol may increase the small risks of asthma deaths and this additional risk is not reduced with the additional use of inhaled steroids. This seems to occur because although LABAs relieve asthma symptoms, they also promote bronchial inflammation and sensitivity without warning. Other side effects may include increased blood pressure, change in heart rate, an irregular heartbeat, increased risk of osteoporosis, cataracts, and glaucoma. No increase in bone loss or osteoporosis was noted in one study of 658 patients on high dose Advair (500 μg fluticasone/50 μg salmeterol twice daily), although the 57% dropout rate over three years may have biased the reported outcome. In order to reduce the side effects of the salmeterol/fluticasone combination, Mometasone furoate nasal sprays are now prescribed.

This article uses material from the Wikipedia article Salmeterol/Fluticasone, which is released under the Creative Commons Attribution-Share-Alike License 3.0.

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