What is/are Silver sulfadiazine?
Silver sulfadiazine (INN, or silvadene) is a topical sulfonamide/silver antibacterial used as a topical cream on burns. Studies have found that silver sulfadiazine may increase healing times; and it is therefore not recommended by the authors of a Cochrane review.
Silver sulfadiazine is typically delivered in a 1% cream or aqueous suspension. Brand names include Silvadene (a genericized trademark), Silverex, Silvazine, Flamazine, Thermazene, and SSD.
A 2012 review reported that topical silver showed worse healing time compared to controls and showed no evidence of effectiveness in preventing wounds infection. A Cochrane systematic review from 2008 found that most of the trials had methodological shortcomings and thus are of little use. Another Cochrane systematic review from 2010 concluded that "There is insufficient evidence to establish whether silver-containing dressings or topical agents promote wound healing or prevent wound infection". Other reviews of the evidence have also concluded that the "quality of the trials was limited". Cochrane has raised concerns about delays in time to wound healing and an increased number of dressing applications when SSD is used.
An aseptic exudate (a clear fluid) may form on the wound's surface. Burning and painful sensations are not uncommon but only temporary. About 0.1 to 1% of patients show hypersensitivity reactions like rashes or erythema multiforme. This is a reaction known from other sulfonamides including antibacterials, thiazide diuretics, and sulfonylurea antidiabetics; but data on the likelihood of cross-allergies are inconsistent.
Incorporation of the silver ions can lead to local argyria (discoloration of the skin), especially if the treated area is exposed to ultraviolet. Generalised argyria with silver accumulation in kidneys, liver and retina has only been found in association with excessive long-term use, or repeated use on severe and heavily inflamed burns. Possible consequences of generalised argyria include interstitial nephritis and anemia
This article uses material from the Wikipedia article Silver sulfadiazine, which is released under the Creative Commons Attribution-Share-Alike License 3.0.